mylan 457 pill

1 Mg Lorazepam manufactured by Mylan Pharmaceuticals

Mylan 457 tablets are actually Lorazepam tablets. The tablets contain 1 mg of Lorazepam (generic for Ativan). Mylan 457 tablets are gray and round, with MYLAN letters and the number 457 divided by a score written on one side.

A company with a reputation for quality, Mylan has pioneered the development and production of sophisticated dosage forms such as extended-release tablets and capsules as well as transdermal patches that deliver medication through the skin.

Mylan 457 Lorazepam is an anti-anxiety medication which has long been a drug of choice for status epilepticus.

Lorazepam is an intermediate acting benzodiazepine and its uniqueness, advantages and disadvantages are largely explained by its pharmacokinetic properties (poor water and lipid solubility, high protein binding and non-oxidative metabolism to a pharmacologically inactive glucuronide form) and by its high relative potency (Lorazepam 1 mg is equal in effect to 457 Mylan pill).

CHILDREN AND THE ELDERLY. The safety and effectiveness of Mylan 457 pills is not well determined in children under 16 years of age, but it is used to treat serial seizures. Dose requirements have to be individualized, especially in the elderly and debilitated patients in whom the risk of oversedation is greater. Long-term therapy may lead to cognitive deficits, especially in the elderly, but this is reversible after a period of discontinuation. Benzodiazepines, including Lorazepam, have been found to increase the risk of falls and fractures in the elderly.

LIVER OR KIDNEY FAILURE. Lorazepam may be safer than most benzodiazepines in patients with impaired liver function. Like oxazepam it does not require hepatic oxidation, but only hepatic glucuronidation into lorazepam-glucuronide. Therefore, impaired liver function is unlikely to result in the drug's to an extent causing adverse reactions. Lorazepam-glucuronide and a small amount of unchanged Lorazepam are excreted by the kidneys, so in renal failure small increases in Lorazepam levels may occur.

WITHDRAWAL SYMPTOMS. On abrupt, or overly rapid discontinuation of Lorazepam, anxiety and signs of physical withdrawal have been observed, similar to those seen on withdrawal from alcohol and barbiturates. Mylan Lorazepam as with other benzodiazepine drugs can cause physical dependence, addiction and what is known as the benzodiazepine withdrawal syndrome. The higher the dose and the longer the drug is taken for the greater the risk of experiencing unpleasant withdrawal symptoms. Withdrawal symptoms can however occur from standard dosages and also after short term use. Benzodiazepine treatment should be discontinued as soon as possible via a slow and gradual dose reduction regime.

Prescribers of Mylan 457 tablets must be alert to the possibility of abuse or diversion for illegitimate use when prescribing for unsupervised outpatients. This applies particularly to patients with past or present substance abuse disorders, as persons with addictive personalities are likelier to abuse medications such as Lorazepam. In addition to recreational use, benzodiazepines may be diverted and used to facilitate crime: criminals may take them to deliberately seek disinhibition before committing crimes (which increases their potential for violence) or they may give them to unwitting victims as date rape drugs, notably with alcohol.

DRUG INTERACTIONS: Mylan 457 Lorazepam pills, as all benzodiazepines, interact with other medications and drugs that slow the brain's processes such as alcohol, barbiturates, and narcotics. There have been cases of marked sedation when Mylan 457's were given to patients taking the tranquilizer loxapine (Loxitane); it is unclear if there is a drug interaction at all, but concern is warranted.

You may also refer to this Mylan 457 identification page.